More recently, platinum based chemotherapy has shown to be of interest in the neoadjuvant setting, before surgery in patients with resectable stage IIIA (Rosell et al, 1994; Roth et al, 1998) and stages I to II disease (Depierre et al, 2002). Combined therapy with a platinum and taxane before surgery has also shown notable results, with a 1 year survival rate of 85 in patients with stages I to IIIa NCSLC reported after treatment with paclitaxel and carboplatin (Pisters et al, 2000). Another large randomised Intergroup trial is ongoing in the United States that is evaluating the efficacy of paclitaxel plus carboplatin in patients with early stage NSCLC..
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